Australian Outback Vacations In Nullarbor

If you want to experience the ultimate in road trips, look no further than the Nullarbor Plain. Nullarbor is derived from two Latin words meaning "no trees" and this is a very accurate description of the area. Although arid and barren, there is not only incredible beauty in this land, but also lots to see. Covering 77,000 square miles, Nullabor is one of the largest semi arid Karst deserts in the world. The gateway to the desert is the Nullarbor Roadhouse, a motel and service station located next to the historic Nullarbor Homestead. North of here are the Murrawijinie Caves which can be toured with National Parks officers. The desert is home to a large network of caves which are dramatically cut into the rocks, and are often multiple kilometers wide.

East of the roadhouse is the Head of Bight, a popular whale watching spot. Here southern right whales can be viewed from May to the end of October as they congregate in groups of up to one hundred individuals. Boardwalks take visitors to lookouts where they can see the whales and also enjoy the breathtaking view of the cliffs that drop from the Nullabor Plain into the ocean below. Another area that should be a stop on all itineraries is the Nullarbor Bunda Cliffs, a series of lookouts that stretch for over two hundred kilometers.

Along the way, try a stop in Iron Knob, and trace the town's importance in the steel industry at the Mining Museum. More than just a place to stop for services, Nundroo offers excellent fishing, surfing, and local history. If you are interested in Aboriginal culture, stop at the Ceduna Aboriginal Arts and Culture Center, where you'll find authentic art and gifts, and the Language Center that is working to preserve the many varied Aboriginal languages.

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Hydroponic Gardening – Managing Pests & Diseases

As with soil-based gardens, hydroponic plants require good pest and disease maintenance controls. Failure to do so creates the same results as with 'ordinary' gardens ie spindly or dead plants. Since the majority of hydroponic plants are fruits and vegetables, that means the plants are not worth eating.

However, managing the hydroponic garden is even trickier, since disease and pests have it much easier in this setting. Plants are continuously kept wet, either immersed in water ('true' hydroponics) or continuously sprayed (aeroponics) or in a permanently wet medium such as perlite or sand. Fortunately, as with soil-based gardens, there is an extensive array of available methods to manage the problem.

Using beneficial life forms is one popular way to control unwanted pests, including certain types of bacteria and fungi. These can help to control spider mites and other invaders by crowding them out, eating them or releasing compounds toxic to the pest. They're known as beneficial organizations because they do all that without damaging the plants themselves.

Different types of pesticides are available, too.

Pesticidal soaps have been in use for centuries and still provide effective and non-toxic ways to keep the pests down. One category called botanicals are compounds released by plants themselves that have been combined into an easy-to-use pest control method. Botanicals break down naturally from exposure to air and water and are brilliant because they leave no harmful chemicals behind.

Neem oil can control over 400 different types of pest that typically invade gardens, including hydroponic ones. A simple spray to the leaves can often eliminate common pests. The bugs absorb the oil, which limits their ability to reproduce, leading to a lower population.

For more serious infestations, many commercial pesticides continue to work well.

White flies, aphids, mites and other pests can be a problem in hydroponic settings, just as in soil-based gardens. Powdery mildew is common. In fact, because of the continuous moisture bugs and pests have a 'friendly' environment. Making it 'unfriendly' is straightforward enough, using fungi and organicides. Sulfur-based compounds can help control white flies, mealy bugs, thrips and more.

Pyrethrum continues to be a safe and effective means of control. Although it sounds man made it is actually derived from flowers. This class of natural compounds released by plants are extracted and used in many commercial insecticides. Dosage is low, so the compound is very safe when used correctly (always read the label). Azatrol is a broad spectrum insecticide that provides another easy control method over most common pests.

Hydroponic gardeners have to exercise additional care when using any disease or pest control method, though. Since no soil is present to hold on to the roots, it's easier to damage a plant when manipulating the leaves and stems. That means that if you pick off mites by hand – an effective method for low-number infestations – it's important to exercise extra care.

Since moisture is present, mildew and other fungi are more common in hydroponic gardens. Keeping leaves dry and just the roots wet will help. Any insecticide sprayed on to your plants or vegetable should be allowed to dry under the grow lights. For aeroponically grown plants, for example, that may require a temporary relocation of the indoor garden.

Preformulation and Formulation Development

Optimizing Conformational Stability and Biological ActivityMaintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate various various buffer, pH, ionic strength, and excipient conditions, and identify the conditions that confer the optimum environment for the therapeutic protein.

Utilizing Advanced Statistical Design for Preformulation Development Preformulation development includes statistical design of experiments, allowing simultaneous evaluation of multiple factors and evaluation of interactions between factors. It is crucial to use advanced biophysical characterization techniques to evaluate the conformational stability of large molecules in addition to traditional methods for evaluation of chemical stability.

A large molecule preformulation development program typically includes the following activities:
Evaluate the effect of pH, buffer type, and ionic strength on solubility.
Evaluate the effect of various excipients on improving solubility if necessary.
Evaluate effects of pH, buffer type, and excipients on conformational stability.
Evaluate the effect of pH, buffers, excipients and ionic strength on physical and chemical stability.
Utilize a statistical design approach to identify the optimal conditions for structural, physical and chemical stability.
Perform forced degradation to elucidate product degradation pathways and to demonstrate the stability-indicating capacity of the analytical methods.
Forced degradation studies typically include restricted oxidation, deamidation, aggregation (via agitation), and / or acid / base hydrolysis.
Evaluation of heat stress, photo stress, and freeze thaw are also performed.

Looking for information on Analytical Development and other related resources?

Formulation Development for Numerous Dosage FormsFormulation development includes dosage forms for parenteral, oral topical and inhalation administration, including liquids, gels, suspensions, emulsions and lyophilized powders. Formulation scientists are highly skilled in the development of the dosage forms most relevant to biotherapeutics, with particular expertise in lyophilization and development of stable liquid formulations for proteins. High concentration antibody formulation development for subcutaneous administration requires particular emphasis on viscosity and tonicity. Lyophilization cycle development is performed in the context of the unique thermodynamic properties of the API to deliver an efficient, scalable, transferable process resulting in optimum product stability and reconfiguration characteristics. Formulation development capabilities also include:

Effect of excipients on solubility, tonicity, and viscosity Evaluation of antioxidant and conservative compatibility Container-closure compatibility Long term and accelerated stability studies.

Advantages of Formulation Development Approach. This outlined approach to preformulation and formulation development result in significant savings to the client by eliminating the variables associated with suboptimal formulations. Preclinical development efforts in PK, PD, ADME and toxicology occur with confidence that additional uncontrollable variables from unstable formulations are not introduced into the study. This benefit extends far into clinical trials as well, where assessment of toxicity, dosage levels and efficiency are substantially influenced by an optimal formulation that preserves the three dimensional conformation of the therapeutic protein. By eliminating uncontrolled stability variables, the focus is placed solely on the therapeutic performance and clinical outcome.

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